Ghana, as in many African countries, is faced with the challenge of sustainably managing electronic waste (e-waste). The country has a legal framework and is in the process of developing a public policy for e-waste management. However, e-waste management remains a major challenge due to weaknesses in the country’s innovation and policymaking process that include inability to cater for the informal sector. This article argues that the current approach to innovation policymaking in Ghana would be inadequate in delivering the goal of sustainable e-waste management. We examine the country’s evolving e-waste management regime and the multiple perspectives of actors with respect to their perceived transformative changes and show that these perspectives and expectations are critical for an e-waste policymaking process. We conclude that policy processes adopted in developing countries for e-waste management should be guided by inclusive policymaking approaches that consider perspectives from informal actors to co-create solutions.