This policy document is a methodological guide designed to help policymakers, innovation practitioners, and facilitators design, structure, and implement Transformative Innovation Policies within place-based and challenge-oriented strategies, such as the RIS3CAT 2030 smart specialisation strategy of Catalonia. It provides conceptual frameworks, tools, principles, and examples to support systemic thinking about innovation aimed at structural change … from Draft support concept guide for making transformative innovation policies